Allopregnanolone is a metabolite of progesterone through the action of the enzymes 5α-reductase (5-AR) and 3α-HSD. Unlike progesterone and 5α-DHP, it is NOT an agonist of the progesterone receptor (PR). However, like progesterone and 5α-DHP, it is an agonist of the GABA receptor and is perhaps the most potent endogenous GABA agonist. Due to its 5-AR derived nature allopregnanolone can serve as a precursor to androgens such as DHT, androstanedione, and androsterone through a recently discovered alternative pathway. Allopregnanolone levels drop in cases of severely downregulated 5-AR activity due to stress, PUFA overload, chronic disease, aging, and administration of 5-AR like finasteride or dutasteride (i.e. the (in)famous Post Finasteride Syndrome (PFS)).
Drops per container: about 250
Each drop contains the following ingredients: